Ontology highlight
ABSTRACT:
SUBMITTER: Vaeth M
PROVIDER: S-EPMC5683398 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Vaeth Martin M Maus Mate M Klein-Hessling Stefan S Freinkman Elizaveta E Yang Jun J Eckstein Miriam M Cameron Scott S Turvey Stuart E SE Serfling Edgar E Berberich-Siebelt Friederike F Possemato Richard R Feske Stefan S
Immunity 20171011 4
Store-operated Ca<sup>2+</sup> entry (SOCE) is the main Ca<sup>2+</sup> influx pathway in lymphocytes and is essential for T cell function and adaptive immunity. SOCE is mediated by Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> (CRAC) channels that are activated by stromal interaction molecule (STIM) 1 and STIM2. SOCE regulates many Ca<sup>2+</sup>-dependent signaling molecules, including calcineurin, and inhibition of SOCE or calcineurin impairs antigen-dependent T cell proliferation. We he ...[more]