Ontology highlight
ABSTRACT:
SUBMITTER: Kong R
PROVIDER: S-EPMC4917739 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160501 6287
The HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the Env-gp41 subunit, is a critical component of the virus-cell entry machinery. Here, we report the identification of a neutralizing antibody, N123-VRC34.01, which targets the fusion peptide and blocks viral entry by inhibiting conformational changes in gp120 and gp41 subunits of Env required for entry. Crystal structures of N123-VRC34.01 liganded to the fusion peptide, and to the full Env trimer, revealed a ...[more]