Ontology highlight
ABSTRACT:
SUBMITTER: Mogus AT
PROVIDER: S-EPMC7765226 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Mogus Alemu Tekewe AT Liu Lihong L Jia Manxue M Ajayi Diane T DT Xu Kai K Kong Rui R Huang Jing J Yu Jian J Kwong Peter D PD Mascola John R JR Ho David D DD Tsuji Moriya M Chackerian Bryce B
Vaccines 20201215 4
Broadly neutralizing antibodies (bnAbs) isolated from HIV-infected individuals delineate vulnerable sites on the HIV envelope glycoprotein that are potential vaccine targets. A linear epitope within the N-terminal region of the HIV-1 fusion peptide (FP8) is the primary target of VRC34.01, a bnAb that neutralizes ~50% of primary HIV isolates. FP8 has attracted attention as a potential HIV vaccine target because it is a simple linear epitope. Here, platform technologies based on RNA bacteriophage ...[more]