Ontology highlight
ABSTRACT:
SUBMITTER: Pinton G
PROVIDER: S-EPMC4924721 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Pinton Giulia G Zonca Sara S Manente Arcangela G AG Cavaletto Maria M Borroni Ester E Daga Antonio A Jithesh Puthen V PV Fennell Dean D Nilsson Stefan S Moro Laura L
Oncotarget 20160301 12
In this report, we show that malignant pleural mesothelioma (MPM) patients whose tumors express high levels of AKT1 exhibit a significantly worse prognosis, whereas no significant correlation with AKT3 expression is observed. We provide data that establish a phosphorylation independent role of AKT1 in affecting MPM cell shape and anchorage independent cell growth in vitro and highlight the AKT1 isoform-specific nature of these effects.We describe that AKT1 activity is inhibited by the loss of SI ...[more]