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Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis.

ABSTRACT: Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (1H-1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.

SUBMITTER: Su CC

PROVIDER: S-EPMC3588100 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Oxygenated Cembranoids from the Soft Coral Sinularia flexibilis.

Su Ching-Chyuan CC Wong Bing-Sang BS Chin Chuen C Wu Yu-Jen YJ Su Jui-Hsin JH

International journal of molecular sciences 20130221 2

Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (1H-1H COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cel ...[more]

PMID: 23429272

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