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Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans.

ABSTRACT: Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first example of biscembranoids featuring a trans-fused A/B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-?? rather than the normal cembranoid-?¹ unit in the endo-Diels-Alder cycloaddition. Compounds 2 and 3 exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 macrophages, with IC₅₀ values being at 18.2 and 32.5 ?M, respectively.

SUBMITTER: Li W

PROVIDER: S-EPMC5408232 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans.

Li Wei W Zou Yi-Hong YH Ge Man-Xi MX Lou Lan-Lan LL Xu Yun-Shao YS Ahmed Abrar A Chen Yun-Yun YY Zhang Jun-Sheng JS Tang Gui-Hua GH Yin Sheng S

Marine drugs 20170323 4

Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first exa ...[more]

PMID: 28333090

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