Ontology highlight
ABSTRACT:
SUBMITTER: Murphy SJ
PROVIDER: S-EPMC4926317 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Murphy Stephen J SJ Hart Steven N SN Halling Geoffrey C GC Johnson Sarah H SH Smadbeck James B JB Drucker Travis T Lima Joema Felipe JF Rohakhtar Fariborz Rakhshan FR Harris Faye R FR Kosari Farhad F Subramanian Subbaya S Petersen Gloria M GM Wiltshire Timothy D TD Kipp Benjamin R BR Truty Mark J MJ McWilliams Robert R RR Couch Fergus J FJ Vasmatzis George G
Cancer research 20151216 3
Many somatic mutations have been detected in pancreatic ductal adenocarcinoma (PDAC), leading to the identification of some key drivers of disease progression, but the involvement of large genomic rearrangements has often been overlooked. In this study, we performed mate pair sequencing (MPseq) on genomic DNA from 24 PDAC tumors, including 15 laser-captured microdissected PDAC and 9 patient-derived xenografts, to identify genome-wide rearrangements. Large genomic rearrangements with intragenic b ...[more]