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Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.

ABSTRACT: Small glutamine-rich tetratricopeptide repeat-containing protein ? (SGTA) has been implicated as a co-chaperone and regulator of androgen and growth hormone receptor (AR, GHR) signalling. We investigated the functional consequences of partial and full Sgta ablation in vivo using Cre-lox Sgta-null mice. Sgta(+/-) breeders generated viable Sgta(-/-) offspring, but at less than Mendelian expectancy. Sgta(-/-) breeders were subfertile with small litters and higher neonatal death (P?

SUBMITTER: Philp LK 

PROVIDER: S-EPMC4928056 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha (SGTA) Ablation Limits Offspring Viability and Growth in Mice.

Philp Lisa K LK   Day Tanya K TK   Butler Miriam S MS   Laven-Law Geraldine G   Jindal Shalini S   Hickey Theresa E TE   Scher Howard I HI   Butler Lisa M LM   Tilley Wayne D WD  

Scientific reports 20160630

Small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) has been implicated as a co-chaperone and regulator of androgen and growth hormone receptor (AR, GHR) signalling. We investigated the functional consequences of partial and full Sgta ablation in vivo using Cre-lox Sgta-null mice. Sgta(+/-) breeders generated viable Sgta(-/-) offspring, but at less than Mendelian expectancy. Sgta(-/-) breeders were subfertile with small litters and higher neonatal death (P < 0.02). Body siz  ...[more]

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