Ontology highlight
ABSTRACT:
SUBMITTER: Stojkovic G
PROVIDER: S-EPMC4929447 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Stojkovič Gorazd G Makarova Alena V AV Wanrooij Paulina H PH Forslund Josefin J Burgers Peter M PM Wanrooij Sjoerd S
Scientific reports 20160701
Oxidative stress is capable of causing damage to various cellular constituents, including DNA. There is however limited knowledge on how oxidative stress influences mitochondrial DNA and its replication. Here, we have used purified mtDNA replication proteins, i.e. DNA polymerase γ holoenzyme, the mitochondrial single-stranded DNA binding protein mtSSB, the replicative helicase Twinkle and the proposed mitochondrial translesion synthesis polymerase PrimPol to study lesion bypass synthesis on oxid ...[more]