Ontology highlight
ABSTRACT:
SUBMITTER: Maurer LM
PROVIDER: S-EPMC4929849 | biostudies-literature | 2015 Jul-Aug
REPOSITORIES: biostudies-literature
Maurer Lisa M LM Ma Wenjiang W Mosher Deane F DF
Critical reviews in biochemistry and molecular biology 20150701 4
Fibronectin is a large vertebrate glycoprotein that is found in soluble and insoluble forms and involved in diverse processes. Protomeric fibronectin is a dimer of subunits, each of which comprises 29-31 modules - 12 type I, two type II and 15-17 type III. Plasma fibronectin is secreted by hepatocytes and circulates in a compact conformation before it binds to cell surfaces, converts to an extended conformation and is assembled into fibronectin fibrils. Here we review biophysical and structural ...[more]