Ontology highlight
ABSTRACT:
SUBMITTER: Kong L
PROVIDER: S-EPMC4931249 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Kong Leopold L He Linling L de Val Natalia N Vora Nemil N Morris Charles D CD Azadnia Parisa P Sok Devin D Zhou Bin B Burton Dennis R DR Ward Andrew B AB Wilson Ian A IA Zhu Jiang J
Nature communications 20160628
The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we investigate the contribution of two Env regions to metastability. First, we computationally redesign a largely disordered bend in heptad region 1 (HR1) of SOSIP trimers that connects the long, central HR1 helix to the fusion peptide, substantially improving the yield of soluble, well-folded trim ...[more]