Ontology highlight
ABSTRACT:
SUBMITTER: Koch K
PROVIDER: S-EPMC5566552 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Koch Kathrin K Kalusche Sarah S Torres Jonathan L JL Stanfield Robyn L RL Danquah Welbeck W Khazanehdari Kamal K von Briesen Hagen H Geertsma Eric R ER Wilson Ian A IA Wernery Ulrich U Koch-Nolte Friedrich F Ward Andrew B AB Dietrich Ursula U
Scientific reports 20170821 1
Broadly neutralizing antibodies (bnAbs) against HIV-1 protect from infection and reduce viral load upon therapeutic applications. However no vaccine was able so far to induce bnAbs demanding their expensive biotechnological production. For clinical applications, nanobodies (VHH) derived from heavy chain only antibodies from Camelidae, may be better suited due to their small size, high solubility/stability and extensive homology to human VH3 genes. Here we selected broadly neutralizing nanobodies ...[more]