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Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells.

ABSTRACT: Pentraxin 3 (PTX3) as an inflammatory molecule has been shown to be involved in immune response, inflammation, and cancer. However, the effects of PTX3 on the biological features of cervical cancer cells in vitro and in vivo have not been delineated. Immunohistochemical staining showed that increased PTX3 expression was significantly associated with tumor grade (P?

SUBMITTER: Ying TH

PROVIDER: S-EPMC4932528 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells.

Ying Tsung-Ho TH Lee Chien-Hsing CH Chiou Hui-Ling HL Yang Shun-Fa SF Lin Chu-Liang CL Hung Chia-Hung CH Tsai Jen-Pi JP Hsieh Yi-Hsien YH

Scientific reports 20160705

Pentraxin 3 (PTX3) as an inflammatory molecule has been shown to be involved in immune response, inflammation, and cancer. However, the effects of PTX3 on the biological features of cervical cancer cells in vitro and in vivo have not been delineated. Immunohistochemical staining showed that increased PTX3 expression was significantly associated with tumor grade (P < 0.011) and differentiation (P < 0.019). Knocking down PTX3 with lentivirus-mediated small hairpin RNA (shRNA) in cervical cancer ce ...[more]

PMID: 27377307

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