Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity.
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ABSTRACT:
SUBMITTER: Hollands A
PROVIDER: S-EPMC4933157 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity.
Hollands Andrew A Corriden Ross R Gysler Gabriela G Dahesh Samira S Olson Joshua J Raza Ali Syed S Kunkel Maya T MT Lin Ann E AE Forli Stefano S Newton Alexandra C AC Kumar Geetha B GB Nair Bipin G BG Perry J Jefferson P JJP Nizet Victor V
The Journal of biological chemistry 20160513 27
Emerging antibiotic resistance among pathogenic bacteria is an issue of great clinical importance, and new approaches to therapy are urgently needed. Anacardic acid, the primary active component of cashew nut shell extract, is a natural product used in the treatment of a variety of medical conditions, including infectious abscesses. Here, we investigate the effects of this natural product on the function of human neutrophils. We find that anacardic acid stimulates the production of reactive oxyg ...[more]
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