Ontology highlight
ABSTRACT:
SUBMITTER: Flipse J
PROVIDER: S-EPMC4933910 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Flipse Jacky J Diosa-Toro Mayra A MA Hoornweg Tabitha E TE van de Pol Denise P I DP Urcuqui-Inchima Silvio S Smit Jolanda M JM
Scientific reports 20160706
The dogma is that the human immune system protects us against pathogens. Yet, several viruses, like dengue virus, antagonize the hosts' antibodies to enhance their viral load and disease severity; a phenomenon called antibody-dependent enhancement of infection. This study offers novel insights in the molecular mechanism of antibody-mediated enhancement (ADE) of dengue virus infection in primary human macrophages. No differences were observed in the number of bound and internalized DENV particles ...[more]