Genetic, Environmental, and Disease-Associated Correlates of Vitamin D Status in Children with CKD.

ABSTRACT:

Background and objectives

Vitamin D deficiency is endemic in children with CKD. We sought to investigate the association of genetic disposition, environmental factors, vitamin D supplementation, and renal function on vitamin D status in children with CKD.

Design, setting, participants, & measurements

Serum 25-hydroxy-vitamin D, 1,25-dihydroxy-vitamin D, and 24,25-dihydroxy-vitamin D concentrations were measured cross-sectionally in 500 children from 12 European countries with CKD stages 3-5. All patients were participants of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease Study, had CKD stage 3-5, and were age 6-18 years old. Patients were genotyped for single-nucleotide polymorphisms in the genes encoding 25-hydroxylase, vitamin D binding protein, 7-d

SUBMITTER: Doyon A 

PROVIDER: S-EPMC4934841 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature