Structure and functions of angiotensinogen.
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ABSTRACT:
SUBMITTER: Lu H
PROVIDER: S-EPMC4935807 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Structure and functions of angiotensinogen.
Lu Hong H Cassis Lisa A LA Kooi Craig W Vander CW Daugherty Alan A
Hypertension research : official journal of the Japanese Society of Hypertension 20160218 7
Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides. Although AGT is generally considered as a passive substrate of the renin-angiotensin system, there is accumulating evidence that the regulation and functions of AGT are intricate. Understanding the diversity of AGT properties has been enhanced by protein structural analysis and animal studies. In addition to whole-body genetic deletion, AGT can be regulated in vivo by cell-specific procedures, adeno-associated viral approac ...[more]
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