Ontology highlight
ABSTRACT:
SUBMITTER: Popovitchenko T
PROVIDER: S-EPMC4935837 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Popovitchenko T T Thompson K K Viljetic B B Jiao X X Kontonyiannis D L DL Kiledjian M M Hart R P RP Rasin M R MR
Scientific reports 20160707
Forkhead-box domain (Fox) containing family members are known to play a role in neocorticogenesis and have also been associated with disorders on the autism spectrum. Here we show that a single RNA-binding protein, Hu antigen R (HuR), dictates translation specificity of bound mRNAs and is sufficient to define distinct Foxp-characterized subpopulations of neocortical projection neurons. Furthermore, distinct phosphorylation states of HuR differentially regulate translation of Foxp mRNAs in vitro. ...[more]