Ontology highlight
ABSTRACT:
SUBMITTER: Arkhipenko A
PROVIDER: S-EPMC4936696 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20160707 7
The Prion Protein (PrP) is an ubiquitously expressed glycosylated membrane protein attached to the external leaflet of the plasma membrane via a glycosylphosphatidylinositol anchor (GPI). While the misfolded PrPSc scrapie isoform is the infectious agent of prion disease, the cellular isoform (PrPC) is an enigmatic protein with unclear function. Of interest, PrP localization in polarized MDCK cells is controversial and its mechanism of trafficking is not clear. Here we investigated PrP traffic in ...[more]