Ontology highlight
ABSTRACT:
SUBMITTER: Duvall JR
PROVIDER: S-EPMC5509442 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
ACS infectious diseases 20170307 5
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of which result in disease relapse. We sought to identify molecules specifically targeting C. difficile in high-throughput screens of our diversity-oriented synthesis compound collection. We identified two scaffolds with apparently nov ...[more]