Ontology highlight
ABSTRACT:
SUBMITTER: Kato N
PROVIDER: S-EPMC5515376 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature 20160907 7625
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection of synthetic compounds that have three-dimensional features reminiscent of natural products and are underrepresented in typical screening collections. We report the identification of such compounds with both previously reported and undescribed mechan ...[more]