Ontology highlight
ABSTRACT:
SUBMITTER: Perlmutter JD
PROVIDER: S-EPMC4947392 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Perlmutter Jason D JD Mohajerani Farzaneh F Hagan Michael F MF
eLife 20160511
We computationally study how an icosahedral shell assembles around hundreds of molecules. Such a process occurs during the formation of the carboxysome, a bacterial microcompartment that assembles around many copies of the enzymes ribulose 1,5-bisphosphate carboxylase/ oxygenase and carbonic anhydrase to facilitate carbon fixation in cyanobacteria. Our simulations identify two classes of assembly pathways leading to encapsulation of many-molecule cargoes. In one, shell assembly proceeds concomit ...[more]