Ontology highlight
ABSTRACT:
SUBMITTER: Galindo A
PROVIDER: S-EPMC4956616 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Galindo Antonio A Soler Nicolas N McLaughlin Stephen H SH Yu Minmin M Williams Roger L RL Munro Sean S
Cell reports 20160630 3
The GTPase Arf1 is the major regulator of vesicle traffic at both the cis- and trans-Golgi. Arf1 is activated at the cis-Golgi by the guanine nucleotide exchange factor (GEF) GBF1 and at the trans-Golgi by the related GEF BIG1 or its paralog, BIG2. The trans-Golgi-specific targeting of BIG1 and BIG2 depends on the Arf-like GTPase Arl1. We find that Arl1 binds to the dimerization and cyclophilin binding (DCB) domain in BIG1 and report a crystal structure of human Arl1 bound to this domain. Residu ...[more]