Ontology highlight
ABSTRACT:
SUBMITTER: Ishida M
PROVIDER: S-EPMC6829661 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Ishida Morié M Bonifacino Juan S JS
The Journal of cell biology 20191001 11
SNARE-mediated fusion of endosome-derived transport carriers with the trans-Golgi network (TGN) depends on the concerted action of two types of tethering factors: long coiled-coil tethers of the golgin family, and the heterotetrameric complex GARP. Whereas the golgins mediate long-distance capture of the carriers, GARP promotes assembly of the SNAREs. It remains to be determined, however, how the functions of these tethering factors are coordinated. Herein we report that the ARF-like (ARL) GTPas ...[more]