Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC4958592 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Wang Ping P Doxtader Katelyn A KA Nam Yunsun Y
Molecular cell 20160630 2
N(6)-methyladenosine (m(6)A) is a prevalent, reversible chemical modification of functional RNAs and is important for central events in biology. The core m(6)A writers are Mettl3 and Mettl14, which both contain methyltransferase domains. How Mettl3 and Mettl14 cooperate to catalyze methylation of adenosines has remained elusive. We present crystal structures of the complex of Mettl3/Mettl14 methyltransferase domains in apo form as well as with bound S-adenosylmethionine (SAM) or S-adenosylhomocy ...[more]