Ontology highlight
ABSTRACT:
SUBMITTER: Wee B
PROVIDER: S-EPMC4960591 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20160726
Glioma cells with stem cell traits are thought to be responsible for tumor maintenance and therapeutic failure. Such cells can be enriched based on their inherent drug efflux capability mediated by the ABC transporter ABCG2 using the side population assay, and their characteristics include increased self-renewal, high stem cell marker expression and high tumorigenic capacity in vivo. Here, we show that ABCG2 can actively drive expression of stem cell markers and self-renewal in glioma cells. Ste ...[more]