Ontology highlight
ABSTRACT:
SUBMITTER: Shin HY
PROVIDER: S-EPMC4963296 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Shin Ha Youn HY Willi Michaela M HyunYoo Kyung K Zeng Xianke X Wang Chaochen C Metser Gil G Hennighausen Lothar L
Nature genetics 20160704 8
Super-enhancers comprise dense transcription factor platforms highly enriched for active chromatin marks. A paucity of functional data led us to investigate the role of super-enhancers in the mammary gland, an organ characterized by exceptional gene regulatory dynamics during pregnancy. ChIP-seq analysis for the master regulator STAT5A, the glucocorticoid receptor, H3K27ac and MED1 identified 440 mammary-specific super-enhancers, half of which were associated with genes activated during pregnanc ...[more]