Dissecting super-enhancer hierarchy based on chromatin interactions.
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ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC5838163 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Dissecting super-enhancer hierarchy based on chromatin interactions.
Huang Jialiang J Li Kailong K Cai Wenqing W Liu Xin X Zhang Yuannyu Y Orkin Stuart H SH Xu Jian J Yuan Guo-Cheng GC
Nature communications 20180305 1
Recent studies have highlighted super-enhancers (SEs) as important regulatory elements for gene expression, but their intrinsic properties remain incompletely characterized. Through an integrative analysis of Hi-C and ChIP-seq data, here we find that a significant fraction of SEs are hierarchically organized, containing both hub and non-hub enhancers. Hub enhancers share similar histone marks with non-hub enhancers, but are distinctly associated with cohesin and CTCF binding sites and disease-as ...[more]
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