Ontology highlight
ABSTRACT:
SUBMITTER: Caliari SR
PROVIDER: S-EPMC4963302 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Caliari Steven R SR Vega Sebastián L SL Kwon Michelle M Soulas Elizabeth M EM Burdick Jason A JA
Biomaterials 20160629
Improved fundamental understanding of how cells interpret microenvironmental signals is integral to designing better biomaterial therapies. YAP/TAZ are key mediators of mechanosensitive signaling; however, it is not clear how they are regulated by the complex interplay of microenvironmental factors (e.g., stiffness and degradability) and culture dimensionality. Using covalently crosslinked norbornene-functionalized hyaluronic acid (HA) hydrogels with controlled stiffness (via crosslink density) ...[more]