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ABSTRACT: Background/aims
The Mycotic Ulcer Treatment Trial I (MUTT I) was a double-masked, multicentre, randomised controlled trial, which found that topical natamycin is superior to voriconazole for the treatment of filamentous fungal corneal ulcers. In this study, we determine risk factors for low vision-related quality of life in patients with fungal keratitis.Methods
The Indian visual function questionnaire (IND-VFQ) was administered to MUTT I study participants at 3 months. Associations between patient and ulcer characteristics and IND-VFQ subscale score were assessed using generalised estimating equations.Results
323 patients were enrolled in the trial, and 292 (90.4%) completed the IND-VFQ at 3 months. Out of a total possible score of 100, the average VFQ score for all participants was 81.3 (range 0-100, SD 23.6). After correcting for treatment arm, each logMAR line of worse baseline visual acuity in the affected eye resulted in an average 1.2 points decrease on VFQ at 3 months (95% CI -1.8 to 0.6, p<0.001). Those who required therapeutic penetrating keratoplasty had an average of 25.2 points decrease on VFQ after correcting for treatment arm (95% CI -31.8 to -18.5, p<0.001). Study participants who were unemployed had on average 28.5 points decrease on VFQ (95% CI -46.9 to -10.2, p=0.002) after correcting for treatment arm.Conclusions
Monocular vision loss from corneal opacity due to fungal keratitis reduced vision-related quality of life. Given the relatively high worldwide burden of corneal opacity, improving treatment outcomes of corneal infections should be a public health priority.Trial registration number
Clinicaltrials.gov Identifier: NCT00996736.
SUBMITTER: Rose-Nussbaumer J
PROVIDER: S-EPMC4965324 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Rose-Nussbaumer Jennifer J Prajna N Venkatesh NV Krishnan Tiruvengada T Mascarenhas Jeena J Rajaraman Revathi R Srinivasan Muthiah M Raghavan Anita A Oldenburg Catherine E CE O'Brien Kieran S KS Ray Kathryn J KJ Porco Travis C TC McLeod Stephen D SD Acharya Nisha R NR Keenan Jeremy D JD Lietman Thomas M TM
The British journal of ophthalmology 20151103 7
<h4>Background/aims</h4>The Mycotic Ulcer Treatment Trial I (MUTT I) was a double-masked, multicentre, randomised controlled trial, which found that topical natamycin is superior to voriconazole for the treatment of filamentous fungal corneal ulcers. In this study, we determine risk factors for low vision-related quality of life in patients with fungal keratitis.<h4>Methods</h4>The Indian visual function questionnaire (IND-VFQ) was administered to MUTT I study participants at 3 months. Associati ...[more]