Ontology highlight
ABSTRACT:
SUBMITTER: Robel S
PROVIDER: S-EPMC4966160 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Robel Stefanie S Sontheimer Harald H
Nature neuroscience 20160101 1
Reactive astrocytes have been proposed to become incompetent bystanders in epilepsy as a result of cellular changes rendering them unable to perform important housekeeping functions. Indeed, successful surgical treatment of mesiotemporal lobe epilepsy hinges on the removal of the glial scar. New research now extends the role of astrocytes, suggesting that they may drive the disease process by impairing the inhibitory action of neuronal GABA receptors. Here we discuss studies that include hyperex ...[more]