Ontology highlight
ABSTRACT:
SUBMITTER: Reck J
PROVIDER: S-EPMC4966982 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Reck Jaimee J Schauer Alexandria M AM VanderWaal Mills Kristyn K Bower Raqual R Tritschler Douglas D Perrone Catherine A CA Porter Mary E ME
Molecular biology of the cell 20160601 15
The assembly of cilia and flagella depends on the activity of two microtubule motor complexes, kinesin-2 and dynein-2/1b, but the specific functions of the different subunits are poorly defined. Here we analyze Chlamydomonas strains expressing different amounts of the dynein 1b light intermediate chain (D1bLIC). Disruption of D1bLIC alters the stability of the dynein 1b complex and reduces both the frequency and velocity of retrograde intraflagellar transport (IFT), but it does not eliminate ret ...[more]