Ontology highlight
ABSTRACT:
SUBMITTER: Zong Y
PROVIDER: S-EPMC4969591 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Zong Yao Y Yuan Yongguang Y Qian Xiaobing X Huang Zhen Z Yang Wei W Lin Leilei L Zheng Qishan Q Li Yujie Y He Huining H Gao Qianying Q
Scientific reports 20160802
Ocular neovascularization (NV) is the primary cause of blindness in many ocular diseases. Large molecular weight anti- vascular endothelial growth factor (VEGF) protein drugs, such as Avastin and Lucentis, have saved the vision of millions. However, approximately 20-30% of patients respond poorly to anti-VEGF treatment. We found that artesunate (ART), a small molecular derivative of artemisinin, had a significant inhibitory effect on ocular NV by downregulating the expression of VEGFR2, PKCα, an ...[more]