Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC4972332 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Huang Yaoxing Y Yu Jian J Lanzi Anastasia A Yao Xin X Andrews Chasity D CD Tsai Lily L Gajjar Mili R MR Sun Ming M Seaman Michael S MS Padte Neal N NN Ho David D DD
Cell 20160601 7
While the search for an efficacious HIV-1 vaccine remains elusive, emergence of a new generation of virus-neutralizing monoclonal antibodies (mAbs) has re-ignited the field of passive immunization for HIV-1 prevention. However, the plasticity of HIV-1 demands additional improvements to these mAbs to better ensure their clinical utility. Here, we report engineered bispecific antibodies that are the most potent and broad HIV-neutralizing antibodies to date. One bispecific antibody, 10E8V2.0/iMab, ...[more]