Ontology highlight
ABSTRACT:
SUBMITTER: Chung CY
PROVIDER: S-EPMC4972459 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Cell reports 20160623 2
Chromatin-mediated processes influence the development and progression of breast cancer. Using murine mammary carcinoma-derived tumorspheres as a functional readout for an aggressive breast cancer phenotype, we performed a loss-of-function screen targeting 60 epigenetic regulators. We identified the Polycomb protein Cbx8 as a key regulator of mammary carcinoma both in vitro and in vivo. Accordingly, Cbx8 is overexpressed in human breast cancer and correlates with poor survival. Our genomic analy ...[more]