Ontology highlight
ABSTRACT:
SUBMITTER: Hams E
PROVIDER: S-EPMC4973506 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Hams Emily E Bermingham Rachel R Wurlod Felicity A FA Hogan Andrew E AE O'Shea Donal D Preston Roger J RJ Rodewald Hans-Reimer HR McKenzie Andrew N J AN Fallon Padraic G PG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20151021 2
Induction of a type 2 cellular response in the white adipose tissue leads to weight loss and improves glucose homeostasis in obese animals. Injection of obese mice with recombinant helminth-derived Schistosoma mansoni egg-derived ω1 (ω1), a potent inducer of type 2 activation, improves metabolic status involving a mechanism reliant upon release of the type 2 initiator cytokine IL-33. IL-33 initiates the accumulation of group 2 innate lymphoid cells (ILC2s), eosinophils, and alternatively activat ...[more]