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The helminth T2 RNase ?1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism.


ABSTRACT: Induction of a type 2 cellular response in the white adipose tissue leads to weight loss and improves glucose homeostasis in obese animals. Injection of obese mice with recombinant helminth-derived Schistosoma mansoni egg-derived ?1 (?1), a potent inducer of type 2 activation, improves metabolic status involving a mechanism reliant upon release of the type 2 initiator cytokine IL-33. IL-33 initiates the accumulation of group 2 innate lymphoid cells (ILC2s), eosinophils, and alternatively activated macrophages in the adipose tissue. IL-33 release from cells in the adipose tissue is mediated by the RNase activity of ?1; however, the ability of ?1 to improve metabolic status is reliant upon effective binding of ?1 to CD206. We demonstrate a novel mechanism for RNase-mediated release of IL-33 inducing ILC2-dependent improvements in the metabolic status of obese animals.

SUBMITTER: Hams E 

PROVIDER: S-EPMC4973506 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism.

Hams Emily E   Bermingham Rachel R   Wurlod Felicity A FA   Hogan Andrew E AE   O'Shea Donal D   Preston Roger J RJ   Rodewald Hans-Reimer HR   McKenzie Andrew N J AN   Fallon Padraic G PG  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20151021 2


Induction of a type 2 cellular response in the white adipose tissue leads to weight loss and improves glucose homeostasis in obese animals. Injection of obese mice with recombinant helminth-derived Schistosoma mansoni egg-derived ω1 (ω1), a potent inducer of type 2 activation, improves metabolic status involving a mechanism reliant upon release of the type 2 initiator cytokine IL-33. IL-33 initiates the accumulation of group 2 innate lymphoid cells (ILC2s), eosinophils, and alternatively activat  ...[more]

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