Ontology highlight
ABSTRACT:
SUBMITTER: Crowley VM
PROVIDER: S-EPMC4979570 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Crowley Vincent M VM Khandelwal Anuj A Mishra Sanket S Stothert Andrew R AR Huard Dustin J E DJ Zhao Jinbo J Muth Aaron A Duerfeldt Adam S AS Kizziah James L JL Lieberman Raquel L RL Dickey Chad A CA Blagg Brian S J BS
Journal of medicinal chemistry 20160404 7
Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and mutant myocilin. Grp94 has been implicated as a target for several therapeutic areas including glaucoma, cancer metastasis, and multiple myeloma. While 85% identical to other Hsp90 isoforms, the N-terminal ATP-bi ...[more]