Ontology highlight
ABSTRACT:
SUBMITTER: Park HW
PROVIDER: S-EPMC4980282 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Park H-W HW Tse S S Yang W W Kelly H W HW Kaste S C SC Pui C-H CH Relling M V MV Tantisira K G KG
The pharmacogenomics journal 20160209 2
Treatment with glucocorticoids is associated with lower bone mineral density (BMD). We performed a genome-wide association study to analyze interactive effects between genotypes and cumulative dose of prednisone (PD) over 4.3 years of follow-up period on the final BMD Z-scores in 461 white children from the Childhood Asthma Management Program. No variants met the conventional criteria for genome-wide significance, and thus we looked for evidence of replication. The top 100-ranked single-nucleoti ...[more]