Native functionality and therapeutic targeting of arenaviral glycoproteins.
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ABSTRACT:
SUBMITTER: Crispin M
PROVIDER: S-EPMC4983490 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Native functionality and therapeutic targeting of arenaviral glycoproteins.
Crispin Max M Zeltina Antra A Zitzmann Nicole N Bowden Thomas A TA
Current opinion in virology 20160419
Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralizing antibodies. Despite significant conservation of the glycoprotein architecture across the arenavirus family, there is considerable variation in the molecular recognition mechanisms used during host cell entry. We review recent progress in dissecting these infection events and describe how arenaviral glycoproteins can be targeted by small-molecule antivirals, ...[more]
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