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Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues.

ABSTRACT: A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5'-O-tritylated and the 5'-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5'O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at ?m concentrations, however significantly weaker potency against YFV.

SUBMITTER: McGuigan C

PROVIDER: S-EPMC4984408 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues.

McGuigan Christopher C Serpi Michaela M Slusarczyk Magdalena M Ferrari Valentina V Pertusati Fabrizio F Meneghesso Silvia S Derudas Marco M Farleigh Laura L Zanetta Paola P Bugert Joachim J

ChemistryOpen 20160121 3

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5'-O-tritylated and the 5'-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5'O, ...[more]

PMID: 27551659

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