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RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modifications.

ABSTRACT: During transcription elongation, RNA polymerase II (pol II) travels along the DNA template across thousands to millions of nucleotides and accurately synthesizes the complementary RNA transcripts. Apart from its canonical function as a key enzyme for DNA-dependent RNA synthesis, pol II also functions as a selective sensor to recognize DNA lesions or epigenetic modifications.

SUBMITTER: Shin JH

PROVIDER: S-EPMC4984683 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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RNA polymerase II acts as a selective sensor for DNA lesions and endogenous DNA modifications.

Shin Ji Hyun JH Xu Liang L Wang Dong D

Transcription 20160422 3

During transcription elongation, RNA polymerase II (pol II) travels along the DNA template across thousands to millions of nucleotides and accurately synthesizes the complementary RNA transcripts. Apart from its canonical function as a key enzyme for DNA-dependent RNA synthesis, pol II also functions as a selective sensor to recognize DNA lesions or epigenetic modifications. ...[more]

PMID: 27105138

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