Ontology highlight
ABSTRACT:
SUBMITTER: Kunkel GH
PROVIDER: S-EPMC4985491 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kunkel George H GH Chaturvedi Pankaj P Tyagi Suresh C SC
Heart failure reviews 20160901 5
Mitochondrial dysfunction underlines a multitude of pathologies; however, studies are scarce that rescue the mitochondria for cellular resuscitation. Exploration into the protective role of mitochondrial transcription factor A (TFAM) and its mitochondrial functions respective to cardiomyocyte death are in need of further investigation. TFAM is a gene regulator that acts to mitigate calcium mishandling and ROS production by wrapping around mitochondrial DNA (mtDNA) complexes. TFAM's regulatory fu ...[more]