Ontology highlight
ABSTRACT:
SUBMITTER: Kang I
PROVIDER: S-EPMC5851836 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Kang Inhae I Chu Charleen T CT Kaufman Brett A BA
FEBS letters 20180215 5
The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mtDNA)-binding protein essential for genome maintenance. TFAM functions in determining the abundance of the mitochondrial genome by regulating packaging, stability, and replication. More recently, TFAM has been shown to play a central role in the mtDNA stress-mediated inflammatory response. Emerging evidence indicates that decreased mtDNA copy number is associated with several aging-related pathologies; however, little is ...[more]