Protein transduction therapy into cochleae via the round window niche in guinea pigs.
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ABSTRACT:
SUBMITTER: Takeda H
PROVIDER: S-EPMC4988354 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Protein transduction therapy into cochleae via the round window niche in guinea pigs.
Takeda Hiroki H Kurioka Takaomi T Kaitsuka Taku T Tomizawa Kazuhito K Matsunobu Takeshi T Hakim Farzana F Mizutari Kunio K Miwa Toru T Yamada Takao T Ise Momoko M Shiotani Akihiro A Yumoto Eiji E Minoda Ryosei R
Molecular therapy. Methods & clinical development 20160817
Cell-penetrating peptides (CPPs) are short sequences of amino acids that facilitate the penetration of conjugated cargoes across mammalian cell membranes, and as such, they may provide a safe and effective method for drug delivery to the inner ear. Simple polyarginine peptides have been shown to induce significantly higher cell penetration rates among CPPs. Herein, we show that a peptide consisting of nine arginines ("9R") effectively delivered enhanced green fluorescent protein (EGFP) into guin ...[more]
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