Ontology highlight
ABSTRACT:
SUBMITTER: Sahu RP
PROVIDER: S-EPMC4991492 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Sahu Ravi P RP Harrison Kathleen A KA Weyerbacher Jonathan J Murphy Robert C RC Konger Raymond L RL Garrett Joy Elizabeth JE Chin-Sinex Helen Jan HJ Johnston Michael Edward ME Dynlacht Joseph R JR Mendonca Marc M McMullen Kevin K Li Gengxin G Spandau Dan F DF Travers Jeffrey B JB
Oncotarget 20160401 15
Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R). As radiation therapy also induces reactive oxygen species, the present studies were designed to define whether ionizing radiation could generate PAF-R agonists and if these lipids could subvert host immunity. We demonstrate that radiation exposure of multiple tumor cell lines in-vitro, tumors in-vivo, and human subjects undergoing radiati ...[more]