Ontology highlight
ABSTRACT:
SUBMITTER: Sahu RP
PROVIDER: S-EPMC4252249 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Sahu Ravi P RP Ocana Jesus A JA Harrison Kathleen A KA Ferracini Matheus M Touloukian Christopher E CE Al-Hassani Mohammed M Sun Louis L Loesch Mathew M Murphy Robert C RC Althouse Sandra K SK Perkins Susan M SM Speicher Paul J PJ Tyler Douglas S DS Konger Raymond L RL Travers Jeffrey B JB
Cancer research 20141010 23
Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs might subvert host immunity by activating PAF-R. Here, we show that PAF-R agonists are produced in melanoma cells by chemotherapy that is administered in vitro, in vivo, or in human subjects. Structural characterization of the PAF-R agonists induce ...[more]