Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis.
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ABSTRACT:
SUBMITTER: Sivanesam K
PROVIDER: S-EPMC4992449 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin-binding geometry hypothesis.
Sivanesam Kalkena K Shu Irene I Huggins Kelly N L KN Tatarek-Nossol Marianna M Kapurniotu Aphrodite A Andersen Niels H NH
FEBS letters 20160708 16
Versions of a previously discovered β-hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the hairpin conformation by a backbone cyclization constraint, display superior activity as inhibitors. The cyclized hairpin, cyclo-WW2, displays inhibitory activity at substoichiometric concentrations relative to this amyloidogenic peptide. The hairpin-binding hypothesis stands confirmed. ...[more]
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