Ontology highlight
ABSTRACT:
SUBMITTER: Sivanesam K
PROVIDER: S-EPMC4992449 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Sivanesam Kalkena K Shu Irene I Huggins Kelly N L KN Tatarek-Nossol Marianna M Kapurniotu Aphrodite A Andersen Niels H NH
FEBS letters 20160708 16
Versions of a previously discovered β-hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the hairpin conformation by a backbone cyclization constraint, display superior activity as inhibitors. The cyclized hairpin, cyclo-WW2, displays inhibitory activity at substoichiometric concentrations relative to this amyloidogenic peptide. The hairpin-binding hypothesis stands confirmed. ...[more]