Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer.

ABSTRACT:

Background

Human papillomavirus (HPV) infection may increase breast cancer (BC) risk.

Methods

To examine this, we used nationwide medical registries to identify all Danish women who underwent conisation to remove HPV-associated cervical precancerous lesions (n=87?782) from 1978 to 2013. We computed the absolute risk of BC and standardised incidence ratios (SIRs) and 95% confidence intervals (95% CIs) for breast cancer, based on national breast cancer incidence rates.

Results

Conisation was associated with slightly increased BC incidence (SIR=1.1, 95% CI=1.0-1.1), and an absolute BC risk of 7.7% (95% CI=7.3-8.1%) in 35.9 years of follow-up. BC risk was elevated throughout follow-up, especially in the first 5 years (<1 year: SIR=1.2, 95% CI=0.92-1.5; 1-5 years: SIR=1.2, 95% CI=1.1-1.3; ?5 years: SIR=1.1, 95% CI=1.0-1.1). Women who underwent conisation and had autoimmune disease had elevated BC risk after 5 years of follow-up (SIR=1.4, 95% CI=1.0-1.8).

Conclusions

BC risk is slightly elevated in women with persistent HPV infection, possibly due to detection bias.

SUBMITTER: Sogaard M 

PROVIDER: S-EPMC4997534 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature