Ontology highlight
ABSTRACT:
SUBMITTER: Sheng Y
PROVIDER: S-EPMC4999606 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Sheng Y Y Soto J J Orlu Gul M M Cortina-Borja M M Tuleu C C Standing J F JF
CPT: pharmacometrics & systems pharmacology 20160729 8
Pharmacodynamic (PD) count data can exhibit bimodality and nonequidispersion complicating the inclusion of drug effect. The purpose of this study was to explore four different mixture distribution models for bimodal count data by including both drug effect and distribution truncation. An example dataset, which exhibited bimodal pattern, was from rodent brief-access taste aversion (BATA) experiments to assess the bitterness of ascending concentrations of an aversive tasting drug. The two generali ...[more]