Ontology highlight
ABSTRACT:
SUBMITTER: Stanfield RL
PROVIDER: S-EPMC5000368 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Stanfield Robyn L RL Wilson Ian A IA Smider Vaughn V VV
Science immunology 20160714 1
A subset of bovine antibodies have an exceptionally long third heavy-chain complementarity determining region (CDR H3) that is highly variable in sequence and includes multiple cysteines. These long CDR H3s (up to 69 residues) fold into a long stalk atop which sits a knob domain that is located far from the antibody surface. Three new bovine Fab crystal structures have been determined to decipher the conserved and variable features of ultralong CDR H3s that lead to diversity in antigen recogniti ...[more]